Zistatin (Simvastatin)

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Brand Name: Zistatin

Generic Name: Simvastatin

Manufacturer/Agent: Cosmos Ltd

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Formulation: tabs

Strength: 20mg

Pack size: 28

Trade Price: KES 570.00

Retail Price: @ KES 27.14

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Class: Statins (Cardiovascular drugs)

Mechanism of Action:

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Synonym: Velastatin

Molecular Formulae: C25H38O5 = 469.4

Precautions: Hypersensitivity. pregnancy. porphyria.

Indications/Uses: Hypercholesterolaemia 10mg nocte.

Interactions: Substrate of cyp3a3/4. inducers eg rifampicin decrease effect while inhibitors eg ketoconazole increase effect of saquinavir

Side Effects: Alopecia. gastro-intestinal disturbances. reversible myositis. hypersensitivity reactions. anaemia. dizziness. peripheral neuropathy. jaundice. hepatitis. paraesthesia.

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